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Acetaldehyde dehydrogenase (EC is the next enzyme after alcohol dehydrogenase (see 103700) in the major pathway of alcohol metabolism. There are 2 commissioned military officer ALDH isozymes in the liver: cytosolic ALDH1 (ALDH1A1; 100640) and mitochondrial ALDH2. (2008) known mitochondrial ALDH2 as an accelerator whose start correlative with reduced ischaemic bosom change in rodent models. A high-throughput screen identified a small building block activator of ALDH2, which they called Alda-1, that, once administered to rats ahead an ischemic event, reduced infarct size by 60%, to the highest degree likely direct its inhibitory consequence on the formation of toxic aldehydes.

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